Halima Chahboune, PhD

Associate Research Scientist of Diagnostic Radiology

Contact

Address:
Yale University, School of Medicine
Magnetic Resonance Research Center
TAC, N144, 300 Cedar Street
New Haven, Connecticut 06520-8043
United States

Email: halima.chahboune@yale.edu
Telephone: (203) 785-2953
Fax: (203) 785-6643

Education

Postdoctoral Training, Diagnostic Radiology, Yale University, 2008

PhD, Biomedical Engineering, University of Lyon-Claude Bernard (France), 2003

Please click here for Curriculum Vitae

Research Interests

My research interests include the development of multi-modal MRI methods to allow whole brain 3D imaging of brain function (fMRI) and anatomy (DTI) at the levels of, and in some cases surpassing, individual cortical columns in rodent brain, as well as making these methods available for neuroscience applications. One of the main directions of my work lies in improving the capabilities of conducting ultra-high-resolution, in vivo DTI in rodent brains. My work with in vivo DTI has major implications for studying childhood developmental disorders. Prior in vitro mouse brain DTI studies in high magnetic fields that reveal tissue anisotropy variations were mainly conducted in fixed brain with signal acquisitions requiring several hours. However it is becoming evident that in vivo DTI of mouse brain should be the ultimate goal for quantitative neurodevelopmental studies in mice so that functional and/or longitudinal studies can complement the DTI scans, as in human studies. Furthermore, I have several ongoing collaborations with Yale neuroscientists in which I am primed to combine fMRI with in vivo DTI.

Selected Publications

1. Chahboune H, Mahdjoub R, Desgoutte P, Rousset C, Briguet A, Cespuglio R. Effects of chloramphenicol on brain energy metabolism using (31)P spectroscopy: influences on sleep-wake states in rat. Journal of neurochemistry, 106(4):1552-62, 2008.
2. Chahboune H, Ment LR, Stewart WB, Ma X, Rothman DL, Hyder. Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging, NMR in biomedicine, 20 (3), 375-82, 2007.
3. B Sorli, J F Chateaux, H Chahboune, B Favre, A Briguet and P Morin. Micro-spectrometer for NMR: analysis of small quantities in vitro, Measurments Science and Technology, 15, 877-880, 2004.
4. O. Fokapu, H. Chahboune, M. Armenean, P. Desgoutte, R. Cespuglio, A. Briguet. Denoising EMG and EEG for monitoring small animal models during NMR experiments, IEEE, 2, 1824-1827, 2001.
5. Selected Book Chapter: H.CHAHBOUNE, P. DESGOUTTE, R. CESPUGLIO, O. FOKAPU, A. BRIGUET. Recording and processing of physiological signal and automatic vigilance state identification. HERMES Science Publications, Instrumentation for physical measurements. volume 2, 389-396, 2001
6. Selected Book Chapter: O. FOKAPU, H.CHAHBOUNE, P. DESGOUTTE, R. CESPUGLIO, A. BRIGUET. Denoising EMG and EEG for monitoring small animal models during NMR experiments. HERMES Science Publications, Instrumentation for physical measurements, volume2, 381-388, 2001.