Basavaraju Ganganna, PhD

Associate Research Scientist of Diagnostic Radiology

Contact

Address:
Yale University, School of Medicine
Magnetic Resonance Research Center
TAC, N144, 300 Cedar Street
New Haven, Connecticut 06520-8043
United States

Email: basavaraju.ganganna@yale.edu
Telephone: (203) 785-6170
Fax: (203) 785-6643

Education

Ph.D. Biophysics (2004), National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Thesis title: "Involvement of Mitochondria in Glutamate Receptor Mediated Neuronal Cell Death"

M.Phil Biophysics (1997), National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India
Thesis title: "Interaction of Tricyclic Antidepressant Drugs with Natural and Model Membranes"

M.Sc Physics (1995), Bangalore University, India

B.Sc Physics, Mathematics, Electronics (1995), Bangalore University, India

Please click here for Curriculum Vitae

Research Interests

I am currently using multimodal (fMRI, electrophysiological, and optical) imaging techniques to understand the relationship between the neuronal activity and the changes in hemodynamic response, which is the basis of BOLD signal. fMRI is currently the most widely used method for brain mapping since it is completely non-invasive and provides high spatial and temporal resolution. Since neuronal activity is energetically expensive and requires a constant supply of oxidative ATP for signaling, it has become evident that energy based imaging would provide an unambiguous window into activities of neuronal ensembles. I am currently investigating the changes in neuronal activity and neurometabolic-neurovascular responses for extremely short stimuli, and the use of dynamic signals to quantify dynamic changes in neuronal energy from calibrated fMRI. I am also studying sensory integration and multisensory integration in the rodent model. I have put my efforts toward the development of stimulation protocols for a variety of modalities: tactile (i.e., forepaw, whisker) and non-tactile (i.e., olfactory, visual) sensory paradigms applied to the anesthetized rat. The main focus is on development and validation of methods for reproducible stimulation of each sensory modality applied independently or in conjunction with one another, both inside and outside the magnet.

Selected Publications

1. Peter Herman, Basavaraju G. Sanganahalli, and Fahmeed Hyder (2008) Multimodal measurements of blood plasma and red blood cell volumes during functional brain activation. J. Cereb. Blood flow and Metab (in press)
2. Basavaraju G. Sanganahalli, Christopher J. Bailey, Peter Herman, and Fahmeed hyder (2008) Tactile and non tactile sensory stimulation for fMRI and neurophysiological studies in Rodents. Dynamic Imaging, Methods in Mol Biol, (ISBN:978-1-9341115-74-9)
3. Basavaraju G. Sanganahalli, Peter Herman, and Fahmeed Hyder (2008) Frequency dependent tactile responses by rat brain measured by functional MRI. NMR Biomed. 2008; 21: 410–416.
4. Ulrich Schridde, Manjula Khubchandani, Joshua E. Motelow, Basavaraju G. Sanganahalli, Fahmeed Hyder, & Hal Blumenfeld (2008) Negative BOLD fMRI with positive changes in neuronal activity Cerebral Cortex, 18(8):1814-27.
5. Natasja J.G. Maandag, Daniel Coman, Basavaraju G. Sanganahalli, Peter Herman, Hal Blumenfeld, Fahmeed Hyder (2007) Energetics of neuronal signaling and fMRI activity. Proc Natl Acad Sci, USA 104(51):20546-51.
6. Basavaraju G Sanganahalli, Joshi PG, Joshi NB (2006) NMDA and non-NMDA receptors stimulation causes differential oxidative stress in rat cortical slices, Neurochem International, 49(5)475-480.
7. Basavaraju G Sanganahalli, Joshi PG, Joshi NB (2005) Xanthine oxidase, nitric oxide synthase and phospholipase A(2) produce reactive oxygen species via mitochondria, Brain Research, 1037(1-2)200-3.
8. Kannurpatti SS, Basavaraju G Sanganahalli, Mishra S, Joshi PG, Joshi NB (2004) Glutamate-induced differential mitochondrial response in young and adult rats, Neurochemistry International, 44(5)361-9.
9. Basavaraju G Sanganahalli, Joshi PG, Joshi NB (2000) Differential effects of tricyclic antidepressant drugs on membrane dynamics--a fluorescence spectroscopic study, Life Sciences, 68(1)81-90.

For a further list of Ganganna's publications, please see PubMed.